Global Veterinary Drug Forum

Full Version: Solutions for the occurrence of cracks in the process of pressing
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1 original accessories

Excessive fibrous ingredients in the prescription, large material elasticity
Oily ingredients in the raw materials, weakening the adhesion between the particles
The crystal form of the raw material: the crystal of the cubic crystal is easy to be directly compressed; when the scaly or needle crystal is directly compressed, it is easy to be layered, and when it is compressed into a tablet, the effervescent excipient is easily delaminated in the tablet. , effervescent after moisture absorption, gas escape
Excessive use of water-based lubricant

2 process

The particles are too strong, the fine powder is too small, or the fine particles are too high, and the moisture of the particles is too high, causing cracks or lumbar cracks due to sticking
Binder type is not suitable
The amount of binder is too small or the concentration is too low. The particles prepared are too loose.

3 equipment

The speed is too fast: the air can't be discharged when the film is pressed, the compression time is too short, the pressure is too fast, the pressure is too high, the elastic recovery rate of the material is increased|The pressure regulator is not locked, causing the pressure to increase the pressure distribution unevenly, and the upper piece is first separated. The binding of the die hole is easy to install the top crack punch; the die ring is not installed flat, one side is biased to one side, and the pressure side is large, and the upper side is rushed or burred, and the rupture piece is pulled up and down when the tablet is pressed. Long rushing pressure is too large and lobes
During storage, the tablet swells (or disintegrates) and lobes
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