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+--- Thread: The difference between Penicillin Potassium and Penicillin Sodium (/showthread.php?tid=26)
The difference between Penicillin Potassium and Penicillin Sodium - admin - 11-03-2018
Penicillin is one of the most widely used drugs in veterinary clinic. It is mainly used to treat various infections caused by Gram-positive bacteria such as Streptococcus and Staphylococcus and some Gram-negative bacteria such as Pasteurella multocida.
The difference between Penicillin Potassium and Penicillin Sodium
Penicillin Potassium and Penicillin sodium are common penicillin antibiotics in daily life. Many farmers are not clear about the difference between the two products. They are often confused in use, which brings certain losses to production. In fact, penicillin potassium and penicillin sodium have great differences in their usage and effect.
1. Penicillin potassium
It dissolves rapidly, but intravenous injection is strictly prohibited. Too fast rate of potassium entering the blood vessel will lead to a rapid increase of blood potassium concentration. Elevated blood potassium will cause sudden cardiac arrest due to painful intramuscular injection. At the same time, potassium ion has a strong stimulating effect on skin and blood vessels. At the same time, too fast intravenous injection will cause excessive blood potassium in the body, causing high blood potassium in the body. Blood potassium disease, injection of penicillin potassium has a strong sense of pain, dilution with benzyl alcohol or lidocaine can reduce the sense of pain. In addition, pain is related to the location of the needle and the speed of pushing the medicine.
Generally penicillin potassium is slightly more expensive than penicillin sodium, and in general, the price is relatively cheap. 16 million penicillin potassium and 16 million penicillin sodium are mainly used for Gram-positive bacteria (staphylococcus, streptococcus, tetanus, etc.). Each intramuscular injection of 50 Jin, three times a day for 3 days.
2. Penicillin sodium
It can be injected intravenously, but it is difficult to dissolve. Generally, according to the condition of the disease, the disease that may cause edema does not use penicillin sodium , and the electrolyte disorder may be caused by the general use of potassium penicillin, such as renal dysfunction or brain edema can use penicillin potassium , and if hyperkalemia is sure to use penicillium. Sodium can also be used in combination.
In drug interactions. Penicillin sodium can reduce the absorption of penicillin sodium when combined with gall. The possible mechanism is penicillin binding to bile. When combined with Jiangdanning, the plasma level of penicillin sodium decreased by 78%-79%, and the area under the plasma concentration-time curve (AUC) decreased by 75%-85%. When combined with methotrexate, due to competing renal tubular secretion, the renal clearance rate of methotrexate can be reduced, and the toxicity of methotrexate can be increased. However, penicillin potassium has no such situation.
In sum, the similarities and differences between penicillin potassium and penicillin sodium are:
Common point: 1, they can cause severe allergic reactions, such as anaphylactic shock.
2. All of them are white crystalline powders, odorless or slightly odorless, with moisture-inducing property, and quickly lose efficacy when exposed to acid, alkali or oxidant.
3. Penicillin sodium (potassium) is also a beta-lactam antibiotic, which has strong antimicrobial activity against Gram-positive bacteria and some gram-negative bacteria.
4, penicillin sodium and potassium salts are also suitable for acute infection caused by sensitive bacteria.
Different points: 1, penicillin G potassium can not be pushed, penicillin sodium can be pushed.
2. Penicillin G potassium can not be used in patients with hyperkalemia, penicillin sodium is not used in patients with hyperkalemia.
3, when penicillin G potassium is dripped, attention should be paid to the rate of drip, not too fast.
4. Local pain is more obvious when potassium salt is injected intramuscularly. Benzyl alcohol solution as diluent can alleviate pain.